Topic : Understanding CML

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What is the role of stem-cell transplants in the TKI era?

Part 1 Throughout the 1990s, stem-cell transplantation provided a possible cure for CML, but its use declined as tyrosine kinase inhibitors (TKIs) became available starting in 2001. Medications were highly effective in controlling CML, could be taken by most people, and were generally
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The evolving role of transplantation in CML

Part 1 A CML therapy that emerged in the 1980s was stem-cell transplantation (SCT) (Thomas and colleagues. Ann Intern Med 1986;104:155-163). The idea was that leukemia originated in the bone marrow, so destroying the bone marrow and replacing it with new cells might cure the disease t
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The CML-IQuestionnaire – Have Your Say

CML-IQ is planning to develop a series of e-booklets for people living with CML. Over the next few months, we’ll be working with nurses specializing in CML to develop these special publications.
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What is a “response”?

When you are first diagnosed with chronic myelogenous leukemia, the first goal is to reduce the very high number of white blood cells (WBC) in the blood stream.
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New 2015 guidelines for CML

The U.S. National Comprehensive Cancer Network (NCCN) has published new guidelines for the treatment of chronic myelogenous leukemia (O’Brien and colleagues).
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10 questions to ask your doctor

When you first learn that you have CML, the news is often such a shock that you can’t even begin to think about the questions you need to ask. The internet can be an essential resource...
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Survival and CML: what the TKI revolution has meant

Life with chronic myelogenous leukemia changed a decade ago with what has been called the TKI revolution. The tyrosine kinase inhibitor (TKI) medications changed not only how CML is treated, but people’s expectations of what can be achieved.
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History of CML

Marking World CML Day – September 22

September 22nd is World CML Day. This day helps to broaden awareness and understanding of chronic myelogenous leukemia (CML), a form of blood cancer that affects approximately 5,000 Canadians.
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Deep molecular response: how to achieve it

In part 1 we looked at how a person’s response to TKI treatment is assessed and the importance of reaching key milestones. In Part 2 we looked at how a faster, deeper molecular response can translate to better outcomes.
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Deep molecular response: beyond MMR

While these standards were being developed, new laboratory techniques were enabling even more sensitive PCR testing for BCR-ABL transcripts. This opened up a new world beyond MMR – to a 4-log reduction, a 4.5-log reduction, and even a 5-log reduction.
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